Research progress on the application of human amniotic membrane in ocular fundus diseases_Chinese Journal of Ocular Fundus Diseases

Authors：

Zhu Fangxing ¹ , Liu Jiandong ² , Gao Rongyu ² , Ren Jiantao ² , Sun Xuequan ² ,  Huang Xudong ²

1. School of Clinical Medicine, Shandong Second Medical University, Weifang 261041, China;
2. Zhengda Guangming Eye Group, Weifang Eye Hospital, Weifang Eye Institute, Weifang 261041, China;

Corresponding author：

Huang Xudong, Email: HXD3333@163.com

Keywords：

Amniotic membrane; Macular hole; Rhegmatogenous retinal detachment; Age related macular degeneration; Review

DOI：

10.3760/cma.j.cn511434-20241210-00480

Video：

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Abstract Full text Figures/Tables Video References Cited by

Human amnion (hAM), as a biomaterial, has made significant progress in the field of ophthalmology, particularly in the treatment of retinal diseases. hAM possesses biological properties such as promoting tissue repair, inhibiting inflammation and neovascularization, and reducing fibrosis, which have led to its promising clinical outcomes in treating macular holes, retinal detachment, proliferative vitreoretinopathy, optic disc depression-related macular detachment, and age-related macular degeneration. The application of hAM can improve surgical success rates and promote vision recovery, with no significant rejection reactions observed due to its low immunogenicity. Nevertheless, the use of hAM still faces challenges in optimizing preparation and storage techniques, enhancing therapeutic efficacy, and reducing the risk of infectious disease transmission. Future research should focus on addressing these issues to further promote the application of hAM in retinal disease treatment and enhance its effectiveness.

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2. De Roth A. Plastic repair of conjunctival defects with fetal membranes[J]. Arch Ophthalmol, 1940, 23(3): 522-525. DOI: 10.1001/archopht.1940.00860130586006.
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4. Kim SJ, Lim JI, Bailey ST, et al. Idiopathic macular hole preferred practice pattern®[J/OL]. Ophthalmology, 2025, 7: E1(20124-12-10)[2025-02-07]. DOI: 10.1016/j.ophtha.2024.12.021. [published online ahead of print].
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7. Shen TY, Hu WN, Cai WT, et al. Effectiveness and safety of trabeculectomy along with amniotic membrane transplantation on glaucoma: a systematic review[J/OL]. J Ophthalmol, 2020, 2020: 3949735[2020-10-09]. https://pubmed.ncbi.nlm.nih.gov/33133675/. DOI: 10.1155/2020/3949735.
8. Sharma R, Nappi V, Empeslidis T. The developments in amniotic membrane transplantation in glaucoma and v-itreoretinal procedures[J]. Int Ophthalmol, 2023, 43(5): 1771-1783. DOI: 10.1007/s10792-022-02570-5.
9. Caporossi T, Tartaro R, Bacherini D, et al. Applications of the amniotic membrane in vitreoretinal surgery[J/OL]. J Clin Med, 2020, 9(8): 2675[2020-08-18]. https://pubmed.ncbi.nlm.nih.gov/32824838/. DOI: 10.3390/jcm9082675.
10. Jirsova K, Jones GLA. Amniotic membrane in ophthalmology: properties, preparation, storage and indications for grafting-a review[J]. Cell Tissue Bank, 2017, 18(2): 193-204. DOI: 10.1007/s10561-017-9618-5.
11. Lacorzana J. Amniotic membrane, clinical applications and tissue engineering. Review of its ophthalmic use[J]. Arch Soc Esp Oftalmol (Engl Ed), 2020, 95(1): 15-23. DOI: 10.1016/j.oftal.2019.09.010.
12. Olaya-CM, Michael F, Fabian G, et al. Role of VEGF in the differential growth between the fetal and placental ends of the umbilical cord[J]. J Neonatal Perinatal Med, 2019, 12(1): 47-56. DOI: 10.3233/NPM-1795.
13. Heerema-McKenney A. Defense and infection of the human placenta[J]. APMIS, 2018, 126(7): 570-588. DOI: 10.1111/apm.12847.
14. Sane MS, Misra N, Quintanar NM, et al. Biochemical characterization of pure dehydrated binate amniotic membrane: role of cytokines in the spotlight[J]. Regen Med, 2018, 13(6): 689-703. DOI: 10.2217/rme-2018-0085.
15. Otani T, Ochiai D, Masuda H, et al. The neurorestorative effect of human amniotic fluid stem cells on the chronic phase of neonatal hypoxic-ischemic encephalopathy in mice[J]. Pediatr Res, 2019, 85(1): 97-104. DOI: 10.1038/s41390-018-0131-8.
16. Kaur J, Bathla SC. Regenerative potential of autologous platelet-rich fibrin with and without amnion membrane in the treatment of Grade-II furcation defects: a clinicoradiographic study[J]. J Indian Soc Periodontol, 2018, 22(3): 235-242. DOI: 10.4103/jisp.jisp_119_18.
17. Murri MS, Moshirfar M, Birdsong OC, et al. Amniotic membrane extract and eye drops: a review of literature and clinical application[J]. Clin Ophthalmol, 2018, 12: 1105-1112. DOI: 10.2147/OPTH.S165553.
18. Riccio M, Marchesini A, Pugliese P, et al. Nerve repair and regeneration: Biological tubulization limits and future perspectives[J]. J Cell Physiol, 2019, 234(4): 3362-3375. DOI: 10.1002/jcp.27299.
19. Lewis GP, Fisher SK. Müller cell outgrowth after retinal detachment: association with cone photoreceptors[J]. Invest Ophthalmol Vis Sci, 2000, 41(6): 1542-1545.
20. 郝玉华, 马景学, 修贺明. 羊膜匀浆治疗实验性孔源性视网膜脱离[J]. 中华眼底病杂志, 2009, 25(1): 47-50. DOI: 10.3760/cma.j.issn.1005-1015.2009.01.013.Hao YH, Ma JX, Xiu HM. Experimental rhegmatogenous retinal detachment treated with amniotic homogenate[J]. Chin J Ocul Fundus Dis, 2009, 25(1): 47-50. DOI: 10.3760/cma.j.issn.1005-1015.2009.01.013.
21. Solomon A, Rosenblatt M, Monroy D, et al. Suppression of interleukin 1alpha and interleukin 1beta in human limbal epithelial cells cultured on the amniotic membrane stromal matrix[J]. Br J Ophthalmol, 2001, 85(4): 444-449. DOI: 10.1136/bjo.85.4.444.
22. Solomon A, Wajngarten M, Alviano F, et al. Suppression of inflammatory and fibrotic responses in allergic inflammation by the amniotic membrane stromal matrix[J]. Clin Exp Allergy, 2005, 35(7): 941-948. DOI: 10.1111/j.1365-2222.2005.02285.x.
23. Caporossi T, Tartaro R, De Angelis L, et al. A human amniotic membrane plug to repair retinal detachment associated with large macular tear[J]. Acta Ophthalmol, 2019, 97(8): 821-823. DOI: 10.1111/aos.14109.
24. Garcin T, Gain P, Thuret G. Epiretinal large disc of blue-stained lyophilized amniotic membrane to treat complex macular holes: a 1-year follow-up[J/OL]. Acta Ophthalmol, 2022, 100(2): e598-e608[2021-05-16]. https://pubmed.ncbi.nlm.nih.gov/33998147/. DOI: 10.1111/aos.14909.
25. Caporossi T, Pacini B, Bacherini D, et al. Human amniotic membrane plug to promote failed macular hole closure[J/OL]. Sci Rep, 2020, 10(1): 18264[2020-10-26]. https://pubmed.ncbi.nlm.nih.gov/33106542/. DOI: 10.1038/s41598-020-75292-2.
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27. Caporossi T, Pacini B, De Angelis L, et al. Amniotic membrane plug to promote chronicpost-traumatic macular hole closure[J]. Ophthalmic Surg Lasers Imaging Retina, 2019, 51(1): 50-52. DOI: 10.3928/23258160-20191211-07.
28. Caporossi T, De Angelis L, Pacini B, et al. A human amniotic membrane plug to manage high myopic macular hole associated with retinal detachment[J/OL]. Acta Ophthalmol, 2020, 98(2): e252-e256[2019-07-18]. https://pubmed.ncbi.nlm.nih.gov/31318489/. DOI: 10.1111/aos.14174.
29. Kumagai K, Furukawa M, Ogino N, et al. Incidence and factors related to macular hole reopening[J]. Am J Ophthalmol, 2010, 149(1): 127-132. DOI: 10.1016/j.ajo.2009.08.002.
30. Kang SW, Ahn K, Ham DI. Types of macular hole closure and their clinical implications[J]. Br J Ophthalmol, 2003, 87(8): 1015-1019. DOI: 10.1136/bjo.87.8.1015.
31. Imai M, Iijima H, Gotoh T, et al. Optical coherence tomography of successfully repaired idiopathic macular holes[J]. Am J Ophthalmol, 1999, 128(5): 621-627. DOI: 10.1016/s0002-9394(99)00200-7.
32. Lee SM, Kwon HJ, Park SW, et al. Microstructural changes in the fovea following autologous internal limiting membrane transplantation surgery for large macular holes[J/OL]. Acta Ophthalmol, 2018, 96(3): e406-e408[2017-06-21]. https://pubmed.ncbi.nlm.nih.gov/28636130/. DOI: 10.1111/aos.13504.
33. Peng J, Chen C, Jin H, et al. Autologous lens capsular flap transplantation combined with autologous blood application in the management of refractory macular hole[J]. Retina, 2018, 38(11): 2177-2183. DOI: 10.1097/IAE.0000000000001830.
34. Rizzo S, Caporossi T, Tartaro R, et al. A human amniotic membrane plug to promote retinal breaks repair and recurrent macular hole closure[J]. Retina, 2019, 39(Suppl 10): S95-S103. DOI: 10.1097/IAE.0000000000002320.
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Chinese Journal of Ocular Fundus Diseases

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