Treatment of antibiotic associated diarrhea by Bifidobacterium tetravaccine in infants in China: a Meta-analysis_West China Medical Journal

Authors：

CHAI Jianhua ,  CHANG Hongmei , LI Lian

Department of Nosocomial Infections, Chongzhou People’s Hospital, Chongzhou, Sichuan 611230, P. R. China;

Corresponding author：

CHANG Hongmei, Email: 2293408083@qq.com

Keywords：

Bifidobacteriumtetravaccine; Infants; Antibiotic associated diarrhea; Meta-analysis

DOI：

10.7507/1002-0179.201502139

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Objective To systematically evaluate the clinical effect and safety of Bifidobacterium tetravaccine tablets in the treatment of antibiotic associated diarrhea (ADD) in infants in China. Methods Randomized controlled trials (RCTs) of treatment of AAD by Bifidobacterium tetravaccine in infants were searched by computer from China Knowledge Resource Integrated Database, VIP and Wanfang Data from their inception to November 2016. Meta-analysis of the data was carried out by RevMan 5.3 software. Results Twelve RCTs were chosen, which included 1 761 infant patients. The Meta analysis showed that the effects of treatment of ADD were significantly superior to those of the control group [OR=5.74, 95%CI (4.14, 7.96),P<0.000 01]. Among the 12 RCTs, 8 had no adverse reactions, while the rest4 articles did not mention adverse reactions. Conclusions Based on the present clinical evidences, treatment of ADD by Bifidobacterium tetravaccine in infants is effective and safe. But due to the small number and different quality of RCTs, this conclusion still needs to be confirmed by large sample, multicenter, and high-quality clinical RCTs.

Citation： CHAI Jianhua, CHANG Hongmei, LI Lian. Treatment of antibiotic associated diarrhea by Bifidobacterium tetravaccine in infants in China: a Meta-analysis. West China Medical Journal, 2017, 32(3): 395-399. doi: 10.7507/1002-0179.201502139 Copy

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2. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions Version 5.1.0. (2011-03-01)[2016-10-01]. http://www.Cochrane-handbook.org.
3. 吕亚清, 宋绍雄, 夏波, 等. 双歧杆菌四联活菌片治疗婴幼儿抗生素相关性腹泻的疗效. 实用临床医学, 2014, 15(9): 78-79, 84.
4. 王妍妍, 关晶, 温韬雪. 思连康改善抗生素相关性腹泻患儿菌群失调随机对照研究. 中国药业, 2016, 25(7): 5-7.
5. 朱红英. 思连康联合思密达治疗婴幼儿肺炎继发腹泻效果观察. 现代医药卫生, 2007, 23(18): 2724-2725.
6. 王安林, 王荣林, 周向阳, 等. 思连康治疗婴幼儿肺炎继发性腹泻55例. 医学信息, 2009, 22(10): 2114-2115.
7. 王慧. 思连康治疗婴幼儿肺炎并发腹泻的疗效观察. 内蒙古中医药, 2013(19): 62-63.
8. 曾国华, 黄艳春. 思连康治疗婴幼儿肺炎继发性腹泻49例疗效分析. 咸宁学院学报: 医学版, 2008, 22(5): 415.
9. 陈静, 王立平. 思连康治疗婴幼儿肺炎继发腹泻疗效观察. 中国医学文摘: 儿科学, 2008, 27(3): 206-207.
10. 周晶明. 双歧杆菌四联活菌片治疗160例婴幼儿抗生素相关性腹泻的临床观察. 中国实用医药, 2009, 4(33): 100-101.
11. 戴文, 冯祖章, 杨三平. 双歧杆菌四联活菌片治疗婴幼儿抗生素相关性腹泻疗效分析. 中国医药指南, 2011, 9(8): 86-87.
12. 张茜. 双歧杆菌四联活菌片治疗抗生素相关性腹泻疗效分析. 医学理论与实践, 2013, 26(12): 1628-1629.
13. 陈卓. 思连康治疗婴幼儿抗生素相关性腹泻的临床观察. 医学信息, 2011, 24(6): 3422-3423.
14. 吴雄基, 陆俏群. 双歧杆菌四联活菌片治疗婴幼儿抗生素相关性腹泻的临床研究. 中国实用医药, 2014, 9(26): 20-21.
15. 凌俊, 谭成林. 双歧杆菌四联活菌片治疗小儿厌食症疗效观察. 吉林医学, 2011, 32(22): 4599.

West China Medical Journal

Treatment of antibiotic associated diarrhea by Bifidobacterium tetravaccine in infants in China: a Meta-analysis

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