Hemodynamic study of personalized Stanford type B aortic dissection based on computational fluid dynamics_Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Authors：

WANG Shiqi ¹ ,  WANG Lingyun ¹ , LIN Zhihong ¹ , ZHU Peng ² , YANG Qian ³ ,  CHEN Jianghua ⁴

1. Department of Mechanical and Electrical Engineering, Xiamen University, Xiamen, 361100, Fujian, P. R. China;
2. Department of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P. R. China;
3. Department of Cardiovascular Surgery, Xiamen Cardiovascular Hospital, Xiamen University, Xiamen, 361004, Fujian, P. R. China;
4. Department of Color Ultrasound, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, 361004, Fujian, P. R. China;

Corresponding author：

WANG Lingyun, Email: wangly@xmu.edu.cn; CHEN Jianghua, Email: 2389189000@qq.com

Keywords：

Computational fluid dynamics; aortic dissection; hemodynamics; fluid solid coupling attempt

DOI：

10.7507/1007-4848.202207018

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To establish a personalized Stanford type B aortic dissection numerical simulation model, and using computational fluid dynamics (CFD) numerical simulation to obtain the hemodynamic behavior and law of the type B aortic dissection at different stages of development. Methods Based on the theory of three-dimensional model reconstruction, we used CT images of a patient with type B aortic dissection in the Xiamen Cardiovascular Hospital of Xiamen University, relevant medical image processing software to reconstruct a personalized aortic three-dimensional model, and CFD to reconstruct the model which was simulated in fluid mechanics. Results The three-dimensional reconstruction model could intuitively observe the changing trend of the false cavity at different stages of the dissection development. Through fluid mechanics simulation, the blood flow rate, pressure, wall shear stress, vascular wall Von Mises stress and other parameters at different stages of the dissection development were obtained. Conclusion The hemodynamic behavior and law of relevant parameters in the development stage of aortic dissection are analyzed. The combination of the values of relevant parameters and clinical medical detection and diagnosis can well predict the development of the disease, and finally provide more theories and methods for the scientific diagnosis of aortic dissection.

Citation： WANG Shiqi, WANG Lingyun, LIN Zhihong, ZHU Peng, YANG Qian, CHEN Jianghua. Hemodynamic study of personalized Stanford type B aortic dissection based on computational fluid dynamics. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2024, 31(4): 594-599. doi: 10.7507/1007-4848.202207018 Copy

1.	张海. B型主动脉夹层介入治疗部分封堵左锁骨下动脉的影响探讨. 中国实用医药, 2018, 13(23): 72-74.
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3.	王进, 刘一帆, 王利, 等. 主动脉夹层研究进展. 实用医院临床杂志, 2016, 13(4): 209-211.
4.	朱泓樵, 李逸明, 周建, 等. 炎症反应参与主动脉夹层临床转归的研究进展. 中国普通外科杂志, 2020, 29(12): 1509-1514.
5.	杨晓冬, 郭伟, 王中华, 等. 主动脉夹层的血流动力学数值仿真. 中国普通外科杂志, 2011, 20(12): 1289-1293.
6.	李艺, 陶凉, 周宏, 等. 计算流体力学在主动脉根部重建手术中的应用. 中国胸心血管外科临床杂志, 2021, 28(12): 1482-1487.
7.	贾文彩. 血压波动性对主动脉夹层发生发展影响的研究进展. 饮食保健, 2019, 6(22): 298.
8.	黄毕, 杨艳敏, 樊晓寒. 主动脉夹层分子机制的研究进展. 中国分子心脏病学杂志, 2014, 14(5): 1103-1105.
9.	曾宇杰. 胸主动脉夹层血液两相流动数值模拟. 浙江大学, 2017.
10.	张薛欢, 李振锋, 许欢明, 等. 基于形态学和血流动力学的B型主动脉夹层病发机理分析. 医用生物力学, 2020, 35(3): 271-275, 283.
11.	林志鸿. 基于CT扫描三维重构的主动脉夹层演化特征的流体力学研究. 厦门大学, 2021.
12.	Beller CJ, Labrosse MR, Thubrikar MJ, et al. Role of aortic root motion in the pathogenesis of aortic dissection. Circulation, 2004, 109(6): 763-769.
13.	林志鸿, 王凌云, 朱鹏, 等. Stanford B型主动脉夹层发展模型的双向流固耦合模拟分析. 中国普通外科杂志, 2021, 30(12): 1468-1476.
14.	冯金华, 杨茂萍, 曹世平, 等. 主动脉夹层与高血压. 高血压杂志, 2003, 11(3): 251-253.
15.	Xiang J, Natarajan SK, Tremmel M, et al. Hemodynamic-morphologic discriminants for intracranial aneurysm rupture. Stroke, 2011, 42(1): 144-152.
16.	Wen CY, Yang AS, Tseng LY, et al. Investigation of pulsatile flowfield in healthy thoracic aorta models. Ann Biomed Eng, 2010, 38(2): 391-402.
17.	Cheng Z, Riga C, Chan J, et al. Initial findings and potential applicability of computational simulation of the aorta in acute type B dissection. J Vasc Surg, 2013, 57(2 Suppl): 35S-43S.

1. 张海. B型主动脉夹层介入治疗部分封堵左锁骨下动脉的影响探讨. 中国实用医药, 2018, 13(23): 72-74.
2. 侯杨峰, 杨文玲. 主动脉夹层发病机制研究的新进展. 心血管病学进展, 2018, 39(5): 847-851.
3. 王进, 刘一帆, 王利, 等. 主动脉夹层研究进展. 实用医院临床杂志, 2016, 13(4): 209-211.
4. 朱泓樵, 李逸明, 周建, 等. 炎症反应参与主动脉夹层临床转归的研究进展. 中国普通外科杂志, 2020, 29(12): 1509-1514.
5. 杨晓冬, 郭伟, 王中华, 等. 主动脉夹层的血流动力学数值仿真. 中国普通外科杂志, 2011, 20(12): 1289-1293.
6. 李艺, 陶凉, 周宏, 等. 计算流体力学在主动脉根部重建手术中的应用. 中国胸心血管外科临床杂志, 2021, 28(12): 1482-1487.
7. 贾文彩. 血压波动性对主动脉夹层发生发展影响的研究进展. 饮食保健, 2019, 6(22): 298.
8. 黄毕, 杨艳敏, 樊晓寒. 主动脉夹层分子机制的研究进展. 中国分子心脏病学杂志, 2014, 14(5): 1103-1105.
9. 曾宇杰. 胸主动脉夹层血液两相流动数值模拟. 浙江大学, 2017.
10. 张薛欢, 李振锋, 许欢明, 等. 基于形态学和血流动力学的B型主动脉夹层病发机理分析. 医用生物力学, 2020, 35(3): 271-275, 283.
11. 林志鸿. 基于CT扫描三维重构的主动脉夹层演化特征的流体力学研究. 厦门大学, 2021.
12. Beller CJ, Labrosse MR, Thubrikar MJ, et al. Role of aortic root motion in the pathogenesis of aortic dissection. Circulation, 2004, 109(6): 763-769.
13. 林志鸿, 王凌云, 朱鹏, 等. Stanford B型主动脉夹层发展模型的双向流固耦合模拟分析. 中国普通外科杂志, 2021, 30(12): 1468-1476.
14. 冯金华, 杨茂萍, 曹世平, 等. 主动脉夹层与高血压. 高血压杂志, 2003, 11(3): 251-253.
15. Xiang J, Natarajan SK, Tremmel M, et al. Hemodynamic-morphologic discriminants for intracranial aneurysm rupture. Stroke, 2011, 42(1): 144-152.
16. Wen CY, Yang AS, Tseng LY, et al. Investigation of pulsatile flowfield in healthy thoracic aorta models. Ann Biomed Eng, 2010, 38(2): 391-402.
17. Cheng Z, Riga C, Chan J, et al. Initial findings and potential applicability of computational simulation of the aorta in acute type B dissection. J Vasc Surg, 2013, 57(2 Suppl): 35S-43S.

Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

Hemodynamic study of personalized Stanford type B aortic dissection based on computational fluid dynamics

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