Objective The aim of this article is to verify the clinical effect of the near-infrared fluorescent liver cancer surgery projection navigation system without display screen. Methods Three patients who need to undergo open hepatectomy for liver cancer in the Affiliated Hospital of Southwest Medical University from March 2021 to May 2021 were included, verifying the accuracy, stability, and time delay effect of the self-developed near-infrared fluorescence projection navigation system for the location of tumor in surgeries. Results The intraoperative tumor location could be accurately displayed by the near-infrared fluorescence projection system and there was no significant difference between the location of the tumor displayed by intraoperative ultrasound. The tumor location displayed by the near-infrared fluorescence projection system was not influenced by the tumor movement and had no visual-time delay. Postoperative pathology confirmed that the projection range was consistent with the tumor range. Conclusion This near-infrared fluorescence projection technology innovates the intraoperative tumor imaging mode and can accurately navigate open hepatectomy in small sample trials, and it is expected to achieve wide clinical application through subsequent iterative optimization and verification.
Citation：
FANG Cheng, WANG Piao, LI Bo, SU Song, CHENG Zhen, GAN Yu, YANG Xiaoli, PENG Fangyi, SUO Yongkuan. The first clinical verification of near-infrared fluorescence projection navigation technology in liver cancer surgery. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2022, 29(8): 1001-1005. doi: 10.7507/1007-9424.202206071
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Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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- 1. Hu Z, Fang C, Li B, et al. First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-Ⅰ/Ⅱ windows. Nat Biomed Eng, 2020, 4(3): 259-271.
- 2. Chen QY, Xie JW, Zhong Q, et al. Safety and efficacy of endocyanine green tracer-guided lymph node dissection during laparoscopic radical gastrectomy in patients with gastric cancer: A randomized clinical trial. JAMA Surg, 2020, 155(4): 300-311.
- 3. Nakaseko Y, Ishizawa T, Saiura A. Fluorescence-guided surgery for liver tumors. J Surg Oncol, 2018, 118(2): 324-331.
- 4. 刘允怡, 方驰华, 王晓颖, 等. 吲哚菁绿分子荧光影像技术诊断原发性肝癌与术中导航操作诊疗规范 (2021版). 中国实用外科杂志, 2021, 41(9): 1002-1013.
- 5. 方程, 王飘, 苏松, 等. 吲哚菁绿荧光成像在再次胆道探查术中的对照研究. 中国普外基础与临床杂志, 2022, 29(6): 711-715.
- 6. Frumovitz M, Plante M, Lee PS, et al. Near-infrared fluorescence for detection of sentinel lymph nodes in women with cervical and uterine cancers (FILM): a randomised, phase 3, multicentre, non-inferiority trial. Lancet Oncol, 2018, 19(10): 1394-1403.
- 7. Ishizawa T, Fukushima N, Shibahara J, et al. Real-time identification of liver cancers by using indocyanine green fluorescent imaging. Cancer, 2009, 115(11): 2491-2504.
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