Clinical analysis of the pulse oxygen saturation and hemoglobin content of the native high-altitude Tibetans_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

BIANBA Qiongda ¹ , XU Yu ² ,  HUANG Liping ¹ , GAO Zhancheng ²

1. Respiratory Department, Tibet Autonomous Region People’s Hospital, Lasa, Tibet 850000, P. R. China;
2. Department of Respiratory and Critical Care Medicine, Peking University People’s Hospital, Beijing 100044, P. R. China;

Corresponding author：

HUANG Liping, Email: 18908917797@189.cn

Keywords：

High altitude area; Tibetan residents; Pulse oxygen saturation

DOI：

10.7507/1671-6205.201610031

Video：

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Objective To observe the changes and influencing factors on pulse oxygen saturation and hemoglobin in Tibetan residents of 4 200 meters above sea level. Methods The health examination data of the Tibetan village residents were collected in Rerong Country, Shannan Prefecture of Tibet autonomous region from January 4 to February 4, 2012. And the information of pulse oxygen saturation was recorded at the same time. The residents were categorized by sex, age and smoking history to observe the difference in each group. Results The clinical data of 234 healthy Tibetan residents were collected with average age of (37.9±13.9) years old, and 97 were male (41.5%). There were no difference in pulse oxygen saturation [(86.1±3.4)% and (86.0±4.7)%, P=0.784) between male and female residents, and heart rate of the male was less than that of the female [(77.9±9.8) bpm and (81.1±12.1) bpm, P=0.036], while the hemoglobin content was higher in male residents [(164.5±15.4) g/L and (139.1±19.2) g/L, P=0.000). With the increase of age, especially in the group older than 60 years, the pulse oxygen saturation significantly decreased (P=0.003), while hemoglobin content showed a gradual increase trend (P=0.000). And in the group which smoking history more than 20 pack-years, the pulse oxygen saturation was lesser than the other groups, and the hemoglobin content increased (P=0.000). Conclusions The pulse oxygen saturation level of Tibetan residents of 4 200 meters above sea level is negatively correlated with age and smoking history, and the level of hemoglobin is positively correlated with age and smoking history. In resting state, there is no significant difference in heart rate between the groups divided by ages.

Citation： BIANBA Qiongda, XU Yu, HUANG Liping, GAO Zhancheng. Clinical analysis of the pulse oxygen saturation and hemoglobin content of the native high-altitude Tibetans. Chinese Journal of Respiratory and Critical Care Medicine, 2018, 17(3): 271-274. doi: 10.7507/1671-6205.201610031 Copy

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6.	Simonson TS, Huff CD, Witherspoon DJ, et al. Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans. Exp Physiol, 2005, 100(11): 1263-1268.
7.	白玛康卓, 巴桑次仁, 次仁央宗, 等. 不同海拔地区世居藏族人群高原红细胞增多症患病率的流行病学调查. 第三军医大学学报, 2016, 38(3): 220-225.
8.	安晶, 包鹤龄, 方利文. 生物燃料烟雾暴露与中国居民慢性阻塞性肺疾病关系 meta 分析. 中国公共卫生, 2016, 32(7): 999-1004.

1. 席焕久. 藏族的高原适应-西藏藏族生物人类学研究回顾. 人类学学报, 2013, 32(3): 247-255.
2. Luks AM, Swenson ER. Pulse oximetry at high altitude. High Alt Med Biol, 2011, 12(2): 109-119.
3. Ross EM, Matteucci MJ, Shepherd M, et al. Measuring arterial oxygenation in a high altitude field environment: comparing portable pulse oximetry with blood gas analysis. Wilderness Environ Med, 2013, 24(2): 112-117.
4. 张北源, 顾勤, 刘宁. 脓毒症患者中心静脉-动脉血二氧化碳分压差与动脉-中心静脉血氧含量差的比值和乳酸的相关性研究. 中国呼吸与危重症监护杂志, 2016, 15(2): 136-141.
5. Fagenholz PJ, Gutman JA, Murray AF, et al. Optic nerve sheath diameter correlates with the presence and severity of acute mountain sickness: evidence for increased intracranial pressure. J Appl Physiol, 2009, 106(4): 1207-1211.
6. Simonson TS, Huff CD, Witherspoon DJ, et al. Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans. Exp Physiol, 2005, 100(11): 1263-1268.
7. 白玛康卓, 巴桑次仁, 次仁央宗, 等. 不同海拔地区世居藏族人群高原红细胞增多症患病率的流行病学调查. 第三军医大学学报, 2016, 38(3): 220-225.
8. 安晶, 包鹤龄, 方利文. 生物燃料烟雾暴露与中国居民慢性阻塞性肺疾病关系 meta 分析. 中国公共卫生, 2016, 32(7): 999-1004.

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Clinical analysis of the pulse oxygen saturation and hemoglobin content of the native high-altitude Tibetans

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