Objective To investigate the characteristics of blood pressure and coronary artery impairment in patients with essential hypertension (EH) combining coronary heart disease (CHD).
Methods A total of 358 patients with EH combining CHD and other 144 patients with CHD were measured with ambulatory blood pressure monitoring (ABPM), and the parameters of ambulatory blood pressure were analyzed. All the patients underwent coronary angiography. The severity of coronary artery stenosis was evaluated in accordance with the number of impaired arteries.
Results Compared to the patients with simplex CHD, those with EH combining CHD had much heavier artery stenosis and more diffuse lesions, with significant differences (χ2=6.03, P=0.019). The 24h systolic blood pressure (SBP), day SBP, night SBP, 24h pulse pressure (PP), day PP and night PP were higher in the patients with EH combining CHD compared to those of the patients with simplex CHD (The t values were 2.580, 2.045, 2.675, 2.037, 2.601, and 1.995, respectively, while the P values were 0.015, 0.037, 0.009, 0.041, 0.017, and 0.047, respectively).
Conclusion Compared to the patients with simplex CHD, the patients with EH combining CHD suffer from much severe coronary artery impairment, so a good controlling of blood pressure is advisable to improve the coronary artery impairment for the patients with EH combining CHD.
Citation：
JIA Shujie,ZHOU Yun,YANG Hongxia,MI Shuhua. Characteristics of Coronary Artery in Patients with Hypertension and Coronary Heart Disease. Chinese Journal of Evidence-Based Medicine, 2011, 11(6): 640-643. doi: 10.7507/1672-2531.20110112
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Copyright © the editorial department of Chinese Journal of Evidence-Based Medicine of West China Medical Publisher. All rights reserved
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刘晓惠, 胡大一, 刘建章, 等. 高血压病人药物治疗期间动态血压变化. 高血压杂志, 1997, 5(1): 59-61.
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许玉韵. 高血压与冠心病. 中国实用内科杂志, 2007, 27(12): 919-920.
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沈小梅, 杨丽峰, 张巨艳, 等. 原发性高血压合并冠心病的临床及冠脉造影分析. 山西医科大学学报, 2006, 37(3): 269-271.
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迟东升, 刘伊丽, 王鹏, 等. 超声心动图观察左室肥厚对评价高血压心肌微血管病变的价值. 第一军医大学学报, 2003, 23(7): 702-705.
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| 13. |
王伟华, 章辉, 陈坤, 等. 高血压病患者血管活性物质水平变化及苯那普利对其干预. 高血压杂志, 1999, 7(5): 224-246.
|
- 1. 1 Alderman MH. Debate: Does it matter how you lower blood pressure?
Curr Control Trials Cardiovasc Med
, 2000, 1(2): 69-71.
- 2. 2 Furberg CD. A new era in hypertension research: discussing the findings of ALLHAT.
Curr Control Trials Cardiovasc Med
, 2001, 2(6): 249-250.
- 3. 3 Nissen SE, Tuzcu EM, Libby P,
et al
. Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure: the CAMELOT study: a randomized controlled trial.
JAMA
, 2004, 292(18): 2217-2225.
- 4. 6 Redon J, Campos C, Narciso ML,
et al
. Prognostic value of ambulatory blood pressure monitoring in refractory hypertension: a prospective study.
Hypertension
, 1998, 31(2): 712-718.
- 5. 10 von Eckardstein A. Risk factors for atherosclerotic vascular disease.
Handb Exp Pharmacol
, 2005, (170): 71-105.
- 6. 简明, 刘国仗, 刘力生, 等. 动态血压监测在高血压临床和研究中的应用. 中华心血管病杂志, 1993, 21(3): 182-184.
- 7. 孙刚, 王峰, 丁燕程, 等. 高血压患者的血压昼夜节律变化与靶器官损害. 高血压杂志, 1997, 5(3): 215-216.
- 8. 俞风, 邹尔斌, 鲍正毅. 高血压病患者动态血压监测与靶器官损害关系的研究. 高血压杂志, 2000, 8(3): 234-236.
- 9. 刘晓惠, 胡大一, 刘建章, 等. 高血压病人药物治疗期间动态血压变化. 高血压杂志, 1997, 5(1): 59-61.
- 10. 许玉韵. 高血压与冠心病. 中国实用内科杂志, 2007, 27(12): 919-920.
- 11. 沈小梅, 杨丽峰, 张巨艳, 等. 原发性高血压合并冠心病的临床及冠脉造影分析. 山西医科大学学报, 2006, 37(3): 269-271.
- 12. 迟东升, 刘伊丽, 王鹏, 等. 超声心动图观察左室肥厚对评价高血压心肌微血管病变的价值. 第一军医大学学报, 2003, 23(7): 702-705.
- 13. 王伟华, 章辉, 陈坤, 等. 高血压病患者血管活性物质水平变化及苯那普利对其干预. 高血压杂志, 1999, 7(5): 224-246.
