How to perform meta-analysis of single nucleotide polymorphism data by Review Manager 5.3 software_Chinese Journal of Evidence-Based Medicine

Authors：

WANG Chaoyang ^1,2 , WENG Hong ³ , JIN Yinghui ^2,3,4 , LI Binghui ^1,2 ,  REN Xuequn ^1,2 ,  ZENG Xiantao ^2,3

1. Department of General Surgery, Huaihe Hospital of Henan University; Center for Evidence-Based Medicine, Huaihe Hospital of Henan University, Kaifeng, 475000, P.R.China;
2. Center for Evidence-Based Medicine, Henan University, Kaifeng 475000, P.R.China;
3. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University; Center for Evidence-Based and Translational Medicine, Wuhan University; Department of Evidence-Based Medicine and Clinical Epidemiology, The Second Clinical College, Wuhan University, Wuhan, 430071, P.R.China;
4. School of Nursing, Tianjin University of Traditional Chinese Medicine; Evidence-Based Nursing Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, P.R.China;

Corresponding author：

REN Xuequn, Email: renxuequn001@163.com; ZENG Xiantao, Email: zengxiantao1128@163.com

Keywords：

Review Manager software; Meta-analysis; Subgroup analysis; Sensitivity analysis; Single nucleotide polymorphism

DOI：

10.7507/1672-2531.201707072

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Abstract Full text Figures/Tables Video References Cited by

To perform a meta-analysis of single nucleotide polymorphism needs to calculate gene frequency. This paper employs allele model as an example to introduce how to calculate gene frequency and display the process of a meta-analysis of single nucleotide polymorphism data using Review Manager 5.3 software.

Citation： WANG Chaoyang, WENG Hong, JIN Yinghui, LI Binghui, REN Xuequn, ZENG Xiantao. How to perform meta-analysis of single nucleotide polymorphism data by Review Manager 5.3 software. Chinese Journal of Evidence-Based Medicine, 2018, 18(2): 244-248. doi: 10.7507/1672-2531.201707072 Copy

1.	Mah JT, Chia KS. A gentle introduction to SNP analysis: resources and tools. J Bioinform Comput Biol, 2007, 5(5): 1123-1138.
2.	Wang Z, Moult J. SNPs, protein structure, and disease. Hum Mutat, 2001, 17(4): 263-270.
3.	曾宪涛, 冷卫东, 郭毅, 等. Meta 分析系列之一: Meta 分析的类型. 中国循证心血管医学杂志, 2012, 4(1): 3-5.
4.	Zeng XT, Liu DY, Kwong JS, et al. Meta-analysis of association between interleukin-1beta C-511T polymorphism and chronic periodontitis susceptibility. J Periodontol, 2015, 86(6): 812-819.
5.	罗杰, 冷卫东, 主编. 系统评价/Meta 分析理论与实践. 北京: 军事医学科学出版社, 2013: 1-558.
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7.	陈月红, 杜亮, 耿兴远, 等. 无对照二分类数据的 Meta 分析在 RevMan 软件中的实现. 中国循证医学杂志, 2014, 14(7): 889-896.
8.	何俐. Cochrane 系统评价软件 RevMan 简介. 中国循证医学杂志, 2001, 1(3): 168-169.
9.	Borenstein M, Hedges LV, Higgins JP, et al. A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods, 2010, 1(2): 97-111.
10.	曾宪涛, Kwong JS, 田国祥, 等. Meta 分析系列之二: Meta 分析的软件. 中国循证心血管医学杂志, 2012, 4(2): 89-91.

1. Mah JT, Chia KS. A gentle introduction to SNP analysis: resources and tools. J Bioinform Comput Biol, 2007, 5(5): 1123-1138.
2. Wang Z, Moult J. SNPs, protein structure, and disease. Hum Mutat, 2001, 17(4): 263-270.
3. 曾宪涛, 冷卫东, 郭毅, 等. Meta 分析系列之一: Meta 分析的类型. 中国循证心血管医学杂志, 2012, 4(1): 3-5.
4. Zeng XT, Liu DY, Kwong JS, et al. Meta-analysis of association between interleukin-1beta C-511T polymorphism and chronic periodontitis susceptibility. J Periodontol, 2015, 86(6): 812-819.
5. 罗杰, 冷卫东, 主编. 系统评价/Meta 分析理论与实践. 北京: 军事医学科学出版社, 2013: 1-558.
6. 陈新林, 胡月, 郎建英, 等. RevMan、Stata 和 R 软件在生存资料 Meta 分析的应用. 中国循证医学杂志, 2016, 16(6): 736-740.
7. 陈月红, 杜亮, 耿兴远, 等. 无对照二分类数据的 Meta 分析在 RevMan 软件中的实现. 中国循证医学杂志, 2014, 14(7): 889-896.
8. 何俐. Cochrane 系统评价软件 RevMan 简介. 中国循证医学杂志, 2001, 1(3): 168-169.
9. Borenstein M, Hedges LV, Higgins JP, et al. A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods, 2010, 1(2): 97-111.
10. 曾宪涛, Kwong JS, 田国祥, 等. Meta 分析系列之二: Meta 分析的软件. 中国循证心血管医学杂志, 2012, 4(2): 89-91.

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How to perform meta-analysis of single nucleotide polymorphism data by Review Manager 5.3 software

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