Objective To investigate the number, distribution and characteristics of the treatment of epilepsy by vagus nerve stimulation (VNS) under China's three-grade diagnosis and treatment system from 2022 to 2023. Methods Researchers from the China Association Against Epilepsy (CAAE) conducted investigations on the number and distribution of epilepsy centers, as well as the number and distribution of VNS treatments for epilepsy from 2022 to 2023 through online and telephone surveys. Results A total of 435 epilepsy centers in China participated in the treatment of epilepsy by VNS under the three-grade system, among which 191 (43.91%) were in the eastern region. From 2022 to 2023, a total of 1 888 VNS procedures were carried out. Among them, 1 255 procedures (66.47%) were carried out in the eastern region; 1 253 procedures (66.37%) were carried out in third-level epilepsy centers, and 635 procedures (33.63%) were carried out in second-level epilepsy centers. Conclusions The promotion and application of VNS for the treatment of epilepsy under China's three-grade diagnosis and treatment system have achieved preliminary outcomes. However, there are still a regional imbalance in the VNS treatment and a shortage of abilities in primary epilepsy c enters.
Citation：
YAN Raowei, ZHAO Chenyang, ZHOU Dong, ZHANG Jianguo, ZHANG Kai, WU Ye, GUAN Yuguang, SUN Jianguang, WU Xintong. Investigation on the current situation of vagus nerve stimulation in the treatment of epilepsy under china's three-grade diagnosis and treatment system. Journal of Epilepsy, 2025, 11(3): 226-230. doi: 10.7507/2096-0247.202503015
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- 1. Ding D, Zhou D, Sander JW, et al. Epilepsy in China: major progress in the past two decades. Lancet Neurol, 2021, 20(4): 316-326.
- 2. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med, 2000, 342(5): 314-319.
- 3. Bauer S, Baier H, Baumgartner C, et al. transcutaneous vagus nerve stimulation (tvns) for treatment of drug-resistant epilepsy: a randomized, double-blind clinical trial (cMPsE02). Brain Stimul, 2016, 9(3): 356-363.
- 4. Handforth A, DeGiorgio CM, Schachter SC, et al. Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial. Neurology, 1998, 51(1): 48-55.
- 5. von Wrede R, Surges R. Transcutaneous vagus nerve stimulation in the treatment of drug-resistant epilepsy. Auton Neurosci, 2021, 235: 102840.
- 6. Lin Y, Hu S, Hao X, et al. Epilepsy centers in China: current status and ways forward. Epilepsia, 2021, 62(11): 2640-2650.
- 7. Schiltz NK, Koroukian SM, Lhatoo SD, et al. Temporal trends in pre-surgical evaluations and epilepsy surgery in the U. S. from 1998 to 2009. Epilepsy Res, 2013, 103(2-3): 270-278.
- 8. Neligan A, Haliasos N, Pettorini B, et al. A survey of adult and pediatric epilepsy surgery in the United Kingdom. Epilepsia, 2013, 54(5): e62-65.
