【摘要】 目的 探讨深吸气量（inspiratory capacity，IC）与慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）患者临床特征的相关性。 方法 2009年12月-2010年6月纳入84例稳定期COPD患者，测定6分钟步行试验（6-minute walk test，6MWT）、圣乔治生活问卷评分（St George′s respiratory questionnaire，SGRQ）及肺功能检查:第1秒用力呼气容积（forced expirotovy volume in one second，FEV1）、IC、IC与肺总量（total lung capacity，TLC）比值（IC/TLC）等相关指标，并进行相关性分析。 结果 6MWT值与FEV1无明显直线相关（r=0.14，P gt;0.1）；6MWT值与FEV1≥60%无明显直线相关（r=0.16，P gt;0.1）；6MWT值与IC值呈正的直线相关（r=0.317，P lt;0.01）；6MWT值与IC/TLC值呈正的直线相关（r=0.274，P lt;0.01）；SGRQ值与FEV1呈负的直线相关（r=-0.307，P lt;0.01）；SGRQ值与IC值无直线相关（r=-0.001，P gt;0.25）；SGRQ值与IC/TLC值无直线相关（r=-0.003，P gt;0.25）。 结论 对COPD患者，IC比FEV1更准确地反映患者的运动耐量的程度，FEV1比IC更准确地反映患者呼吸困难的严重程度。
【Abstract】 Objective To explore the relationship between the inspiratory capacity (IC) and clinical characters of stable chronic obstructive pulmonary disease (COPD). Methods Between December 2009 and June 2010, 84 patients with stable COPD were enrolled. Lung function (FEV1, IC, IC/TLC) ,6 minute walk-test (6MWT) and St George′s respiratory questionnaire (SGRQ) were examined. The relationship among FEV1, IC, IC/TLC, and the results of 6MWT and SGRQ by Pearson correlation analysis. Results There was no linear correlation between 6MWT and FEV1 （r=0.14，P gt;0.1）, and 6MWT and FEV1≥60% （r=0.16，P gt;0.1）. There was positive correlation between 6MWT and IC （r=0.317，P lt;0.01）, and 6MWT and IC/TLC （r=0.274，P lt;0.01）. There was negative correlation between SGRQ and FEV1 （r=-0.307，P lt;0.01）; and no linear correlation between SGRQ and IC （r=-0.001，P gt;0.25）, and SGRQ and IC/TLC （r=-0.003，P gt;0.25）. Conclusion In stable COPD patients, IC may be more accurate than FEV1 in refection of exercise tolerance while FEV1 may be more sensitive than IC in evaluation of dyspnea.
Citation：
LIU Bo,WANG Jun,LI Keke,LIU Xiao. Relationship between the Inspiratory Capacity and Clinical Characters of Stable Chronic Obstructive Pulmonary Disease. West China Medical Journal, 2011, 26(12): 1822-1824. doi:
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- 1. O′Donnell DE,Revill SM, Webb KA. Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary desease[J]. Am J Respir Crit Care Med, 2001, 164(5): 770-777.
- 2. Diaz O, Villafranca C, Ghezzo H, et al. Role of inspiratory capacity on exercise tolerance in COPD patients with and without tidal exoiratory flow limitation at rest[J].Eur Respir J, 2000, 16(2): 269-275.
- 3. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南[J]. 中华结核和呼吸杂志, 2007, 30(1): 8-17.
- 4. O′Donnell DE. Assessment of bronchodilator efficacy in symptomatic. COPD: is spirometry useful?[J]. Chest, 2000, 117(suppl 2): 42-47.
- 5. 陈宇清, 周新, 朱东, 等. 稳定期Ⅱ、Ⅲ级慢性阻塞性肺疾病患者的吸气分数与呼吸肌力研究[J]. 诊断理论与实践, 2007, 6(5): 409-411.
- 6. O′Donnell DE, Flüge T, Gerken F, et al Effects cf tiotropium on lung hyperinflation,dyspnoea and exercise to lerance in COPD[J]. Eur Respir J, 2004, 23(6): 832-840.
- 7. 高晓方. 慢阻肺患者:GOLD分级有待改进[N]. 中国医学论坛报, 2010-09-09(A3).
- 8. 砾石. COPD患者病情越重心腔体积越小[N]. 中国医学论坛报, 2010 -07-15(A6).
- 9. Man WDC, Mustfa N, Nikotou D, et al. Effects salmeterol on resoiratory muscle activity during exercise in poorly reversible COPD[J]. Thorax, 2004, 59(6): 471-476.
- 10. Gelb AF, Gutierrez CA, Weisman IM, et al. Simplified detection of dynamic hyperinflation[J]. Chest, 2004, 126(6): 1855-1860.
- 11. 陈文彬, 潘祥林, 康熙雄, 等. 诊断学[M]. 6版. 北京: 人民卫生出版社, 2004: 33.
- 12. 蔡伯蔷. 提高COPD管理水平, 2010年GSK全国呼吸专家COPD高峰论坛会议纪要[N]. 中国医学论坛报, 2010-07-29(A17).
