Objective To investigate the expression of cerb B2 and CathepsinD in gastric carcinoma and its correlation with the biological behavior of gastric carcinoma (GC). MethodsThe expression was studied by immunohistochemical technique. The expression of cerb B2 and CathepsinD were analyzed with their relation to histologic types, depth of invasion, growth pattern, lymph node metastasis and prognosis of gastric carcinoma. ResultsThirtynine of the 102 gastric carcinoma specimens (38.24%) were positive for cerb B2 and correlated with depth of invasion (P＜0.05) and lymph node metastasis (P＜0.05); eightythree of the 102 gastric carcinoma specimens (81.37%) were positive for CathepsinD and correlated with depth of invasion (P＜0.05), growth pattern (P＜0.05), lymph node metastasis (P＜0.05) and blood vessels cancer embolus (P＜0.05). Prognosis of patients with gastric carcinoma with positive expression of cerb B2 or CathepsinD was poor. The 5year survival rate was significantly lower in gastric carcinoma patients with positive expression of cerb B2 or CathepsinD. Conclusion cerb B2 and CathepsinD are highly related to growth, invasion, metastasis and prognosis of gastric carcinoma.
Citation：
LI Min,CHEN Jian,JIANG Min,et al. The Expression of cerb B2 and Cathepsin D in Gastric Carcinoma and Its Correlation to the Biological Behavior of Gastric Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(2): 108-111. doi:
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- 1. 陈艺华,董敬朋,李春德,等.人乳腺癌cerb B2基因扩增及过度表达的研究 [J].中华肿瘤杂志，1995; 17(1)∶16.
- 2. 万德森.cerb B2/neu基因表达水平与结、直肠癌预后的关系 [J].中山医科大学学报,1994; 15(2)∶120.
- 3. 山际裕史,马玉峰.胃的肠上皮化生及分化型腺癌EGF、EGFR、PCNA、cerb B2、p53及Kras的免疫组化染色研究 [J].国外医学分子生物学分册,1994; 16(6)∶283.
- 4. Akira MD,Masahiko MD,Takeshi MD,et al. Clinical significance of epidermal growth factor (EGF), EGF receptor, and cerb B2 in human gastric cancer [J].Cancer,1995; 75(6)∶1418.
- 5. Shinya MD,Hitoshi MD,Keiichi MD,et al. Overexpression of cerb B2 protein in gastric cancer [J].Cancer, 1993; 72(11)∶3179.
- 6. Garcia M,Deroc D,Pujol P,et al. Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency [J].Oncogene,1990; 5(12)∶1809.
- 7. McGuire WI, Tandon AK, Allred DC, et al. Prognosis and treatment decision in patients with breast cancer without axillary node involvement [J].Cancer,1992; 70(6 Supp1)∶1775.
- 8. Kiluk M,Skrzydlewski Z, Kiluk A, et al.Activity of cathepsin D in some neoplasms of gastrointestinal tract [J]. Pol Merkuriuszlek, 1997; 2(11)∶307.
- 9. Kantsaliev AL, Kozyreva EA, Kushlinskii NE, et al. Cathepsin D activity in gastric cancer [J]. Vopr Onkol,1994; 40(1-3)∶40.
