ObjectiveTo evaluate the effect of polymorphonuclear neutrophils (PMN) on liver damage in acute pancreatitis. MethodsSeventytwo wistar rats were randomly divided into acute pancreatitis (AP) group, acute pancreatitis with PMN depleted (APD) group and sham operation (SO) group. Liver damage was assessed by histological changes and the level of alanine aminotransferase (ALT) in serum. The number of PMN infiltration in liver was reflected by myeloperoxidase (MPO). ResultsMPO significantly increased from 6 to 24 hours in AP and APD groups. However, the level of MPO was significantly higher in AP group than that in APD group. ALT significantly increased from 3 to 24 hours in these two groups, but the level of ALT was significantly lower in APD group than that in AP group. Meanwhile, the hepatic pathological changes were more severe in AP group than that in APD group. ConclusionPMN play an important role in liver damage during acute pancreatitis.
Citation：
SHI Li,TIAN Fuzhou,HUANG Darong,et al.. Effect of Polymorphonuclear Neutrophils on Liver Damage in Acute Pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(5): 332-334. doi:
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- 4. 王晓军,罗向东, 罗勤,等. 严重烧伤早期粘附分子的表达对中性粒细胞在肝脏中聚集的影响 [J]. 中华整形烧伤外科杂志, 1998； 14(4)∶258.
- 5. Provost P, Borgeat P, Merhi Y. Platelets, neutrophils, and vasoconstriction after arterial injury by angioplasty in pigs: effects of MK886, a leukotriene biosynthesis inhibitor [J].Br J Pharmacol, 1998； 123(2)∶251.
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- 7. Weichert W, Bredin HK. A PAFacether antagonist(N 4870 RP/Rhonepoulenc) and laserinduced thrombin in rat mesenteric vessels [J]. Haemostasis, 1989； 19(4)∶229.
- 8. Selak MA, Smith JB. Plateletactivating factorinduced calcium mobilization in human platelets and neutrophils: effects of PAFacether antagonist [J]. J Lipid Mediat, 1989； 1(2)∶125.
