Objective
To investigate the expressions of insulin like growth factor binding protein -3 （ IGFBP-3 ） in serum and bronchoalveolar lavagae fluids （ BALF ） of patients with non-small cell lung cancer ， and explore the clinical significance in dignosis and prognosis of lung cancer.Methods The bronchoalveolar lavagae fluids （ BALF ） were collected by bronchoscopy in 80 cases with non-small cell lung cancer and 14 healthy subjects.The expression of IGFBP-3 in serum and BALF were detected by immunoradioassay.Results The expression of IGFBP-3 in serum and BALF of lung cancer group were significantly lower than that of health group（P lt;0.05）.IGFBP-3 levels were significantly lower in those patients with lymphoid node metastasis or metastasis or TNMⅢ-TNMⅣ than those without metastasis or TNMⅠ-TNMⅡ（P lt;0.05）.In lung cancer group，the levels of the IGFBP-3 in serum and BALF had a significantly positive correlation（r=0.415，r=0.355，P lt;0.01）.Conclusion The IGFBP-3 may play an important role in the development of non-small cell lung cancer and is valuable in dignosis and prognosis of lung cancer.
Citation：
PI Jiali ,XU Ping,SONG Weidong,LIU Yuanyuan.. Clinical significance of insulin like growth factor binding protein 3 in patients with lung cancer. Chinese Journal of Respiratory and Critical Care Medicine, 2008, 08(1): 57-60. doi:
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Copyright © the editorial department of Chinese Journal of Respiratory and Critical Care Medicine of West China Medical Publisher. All rights reserved
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- 1. Grimberg A，Cohen P.Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis.J Cell Physiol，2000，183：1-9.
- 2. Li BD，Khosravi MJ，Berkel HJ，et al.Free insulin-like growth factor-I and breast cancer risk.Int J Cancer，2001，91：736-739.
- 3. Baxter RC.Signalling pathways involved in antiproliferative effects of IGFBP-3：a review.Mol Pathol，2001，54：145-148.
- 4. Rajah R，Valentinis B，Cohen P.Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta1 on programmed cell death through a p53- and IGF-independent mechanism.J Biol Chem，1997，272：12181-12188.
- 5. Hochscheid R，Jaques G，Wegmann B.Transfection of human insulin-like growth factor-binding protein-3 gene inhibits cell growth and tumorigenicity：a cell culture model for lung cancer.J Endocrinol，2000，166：553-563.
- 6. Butt AJ，Firth SM，King MA，et al.Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells.J Biol Chem，2000，275：39174-39181.
- 7. Devi GR，Sprenger CC，Plymate SR，et al.Insulin-like growth factor binding protein-3 induces early apoptosis in malignant prostate cancer cells and inhibits tumor formation in vivo.Prostate，2002，51：141-152.
- 8. MacDonald RG，Schaffer BS，Kang IJ，et al.Growth inhibition and differentiation of the human colon carcinoma cell line，Caco-2，by constitutive expression of insulin-like growth factor binding protein-3.J Gastroenterol Hepatol，1999，14：72-78.
- 9. Buckbinder L，Talbott R，Velasco-Miguel S，et al.Induction of the growth inhibitor IGF-binding protein 3 by p53.Nature，1995，377：646-649.
- 10. Christoph F，Weikert S，Kempkensteffen C，et al.Promoter hypermethylation profile of kidney cancer with new proapoptotic p53 target genes and clinical implications.Clin Cancer Res，2006，12：5040-5046.
