【摘要】 目的 探讨灯盏花素注射液联合血管紧张素转换酶抑制剂（ACEI）依那普利治疗糖尿病早期肾病的临床效果。 方法 2006年10月-2009年12月，将59例临床确诊2型糖尿病早期肾病的患者随机分为治疗组（n=30）与对照组（n=29）。对照组在基本治疗的基础上应用依那普利，治疗组在基本治疗的基础上联合应用依那普利和灯盏花素注射液，疗程均为3周。观察治疗前后两组患者24 h尿微量白蛋白排泄率（UAER）、全血黏度、血浆黏度、甘油三酯（TG）、尿素氮（BUN）、血肌酐（SCr）的变化。 结果 两组患者治疗前后自身对比，24 h UAER均有明显下降（P lt;0.05）；治疗组UAER下降较对照组更为明显（P lt;0.05）。 结论 ACEI联合灯盏花素，其降低24 h UAER疗效优于单纯ACEI疗效，还可有效降低全血黏度和血浆黏度，降低纤维蛋白原含量，改善患者血液流变性。
【Abstract】 Objective To investigate the therapeutic effects of breviscapine combined with angiotensin converting enzyme inhibitor (enalapril) on early diabetic nephropathy. Methods A total of 59 patients with early diabetic nephropathy diagnosed between October 2006 and December 2009 were randomly divided into treatment group (n=30) and control group (n=29). The patients in treatment group were treated by breviscapine combined with enalapril, while the patients were treated with only enalapril in the control group. All of the patients were treated for three weeks. Urinaryalbuminexcretion (UAE), whole blood viscosity, plasma viscosity, triglycercide, blood urea nitrogen and serum creatinine in the two groups were detected before and after the treatment. Results After the threatment, UAE decreased in both of the two groups compared with the value before the treatment (P lt;0.05); the decrease in treatment groups was more obvious than that in the control group (P lt;0.05). Conclusion The combination of breviscapine and enalapril is effective on early diabetic nephropathy.
Citation：
ZHONG Li,LI Ke. Therapeutic Effect of Breviscapine Combined with Enalapril on Early Diabetic Nephropathy. West China Medical Journal, 2011, 26(4): 493-495. doi:
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Copyright © the editorial department of West China Medical Journal of West China Medical Publisher. All rights reserved
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- 2. Wolf G, Chen S, Ziyadeh FN. From the periphery of the glomerular capillary wall toward the center of disease podocyte injury comes of age in diabetic nephropathy[J]. Diabetes, 2005, 54(6): 1626-1634.
- 3. 占永力, 岳玉和, 周静媛, 等. 中药三七注射液对显性糖尿病肾病并高凝状态的影响[J]. 中国中西医结合肾病杂志, 2002, 3(1): 23-25.
- 4. 李春保, 王林辉, 梅小斌. 糖尿病性肾病[M]. 上海: 第二军医大学出版社, 2005: 24-25.
- 5. 郭永兵. 灯盏细辛、 黄芪注射液联合苯那普利治疗IgA肾病伴慢性肾功能不全[J]. 中原医刊, 2006, 33(15): 9-11.
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- 8. 沈东波, 高原, 杜飞. 灯盏花素在大鼠糖尿病早期对近球小管钠钾ATP酶活性的影响[J]. 中国药理学通报, 2007, 23(7): 917-920.
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