Objective To study the variety and the action of inflammatory cytokines and the relevant anti-inflammatory factors in acute pancreatitis (AP).
Methods The authors observed the change of peripheral blood IL-6 and sTNFR in 41 patients with mild and severe AP in two groups on 1, 5, 14d after acute attack by ELISA.
Results All cases recovered gradually in mild group (n＝22) after five days. Twelve patients improved gradually in severe group (n＝19) after 5-7 days. The level of sTNFR increased markedly in 2 groups at 1, 5, 14d(Ｐ＜0.001), and that of the severe group was markedly higher decreased gradually (Ｐ＜0.01). The level of IL-6 increased apparently only in severe group on 1d, 40.38 pg/ml∶12.4 pg/ml, (Ｐ＜0.001). The levels of IL-6 and sTNFR correlated respectively with severity of AP.
Conclusion These results show that peripheral blood IL-6 and TNFα are useful index to supervise the severity and conversion and final results of AP.
Citation：
LI Yun,QIAN Jiaoqin,QIN Renyi,et al.. VARIETY AND CLINICAL SIGNIFICANCE OF IL-6 AND sTNFR LEVELS IN ACUTE PANCREATITIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2000, 7(5): 313-314. doi:
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Hughes CB, Gaber LW, Mohey elDin AB, et al. Inhibition of TNFα improves survival in an experimental model of acute pancreatitis 〔Ｊ〕. Am Surg, 1996; 62(6)∶8.
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Beaux AC, Goldie AS, Ross JA, et al. Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis 〔Ｊ〕. Br J Surg, 1996; 83(3)∶349.
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Laser HG, Gross V, Scheibenbogen C, et al. Elevation of interleukin6 concentration precedes acutephase response and reflects severity in acute pancreatitis 〔Ｊ〕. Gastroenterology, 1991; 101(3)∶782.
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曹雪涛. 可溶性肿瘤坏死因子受体及其临床意义 〔Ｊ〕. 国外医学免疫学分册， 1994； 23(2)∶57.
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- 1. 秦保明主编. 胰腺炎 〔M〕. 第1版. 河南： 河南医科大学出版社， 1996∶108～111.
- 2. Heath DI, Cruickshank AC, Shenkin A, et al. Interleukin6, a mediator of the acute phase response in acute pancreatitis 〔Ｊ〕? Gut, 1989; 30(2)∶A1458.
- 3. Vieema JA, PirezMateo M, Dominguez JE, et al. Role of interleukin6 in acute pancreatitis. Comparison with Creactive protein and phospholipase A 〔Ｊ〕. Gut, 1992; 33(3)∶1264.
- 4. Hughes CB, Gaber LW, Mohey elDin AB, et al. Inhibition of TNFα improves survival in an experimental model of acute pancreatitis 〔Ｊ〕. Am Surg, 1996; 62(6)∶8.
- 5. Beaux AC, Goldie AS, Ross JA, et al. Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis 〔Ｊ〕. Br J Surg, 1996; 83(3)∶349.
- 6. Laser HG, Gross V, Scheibenbogen C, et al. Elevation of interleukin6 concentration precedes acutephase response and reflects severity in acute pancreatitis 〔Ｊ〕. Gastroenterology, 1991; 101(3)∶782.
- 7. 曹雪涛. 可溶性肿瘤坏死因子受体及其临床意义 〔Ｊ〕. 国外医学免疫学分册， 1994； 23(2)∶57.
