Research on direct economic burden and its impact factors in hospitalized patients with amyotrophic lateral sclerosis underwent percutaneous endoscopic gastrostomy_West China Medical Journal

Authors：

LIANG Yan , LIU Yourong , HUANG Jing , GAO Mingyue , HU Linxue ,  CHEN Dezhi

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

CHEN Dezhi, Email: 737238683@qq.com

Keywords：

Amyotrophic lateral sclerosis; percutaneous endoscopic gastrostomy; economic burden

DOI：

10.7507/1002-0179.202410312

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objectives To investigate the economic burden of percutaneous endoscopic gastrostomy (PEG) in hospitalized patients with amyotrophic lateral sclerosis (ALS) and analyze its influencing factors. Methods Clinical data of ALS patients who underwent PEG between 2014 and 2024 were collected through the inpatient electronic medical record system of West China Hospital of Sichuan University (including age, gender, comorbidities, disease course, daily living abilities, length of hospital stay, hospitalization costs, etc.), and their impact on the total hospitalization expenses were studied. Results A total of 102 patients were included. The median total hospitalization cost for ALS patients undergoing PEG was 12 701.00 (10 412.75, 16 720.00) yuan. The results of multiple linear regression analysis showed that the length of hospital stay and age of patients could affect the total hospitalization cost. Conclusions The total medical expenses for ALS patients undergoing PEG are approximately 10 000 yuan. Early assessment of the disease status in ALS patients, providing individualized management, and optimizing treatment plans to reduce hospital stay and medication costs can effectively control medical expenses.

Citation： LIANG Yan, LIU Yourong, HUANG Jing, GAO Mingyue, HU Linxue, CHEN Dezhi. Research on direct economic burden and its impact factors in hospitalized patients with amyotrophic lateral sclerosis underwent percutaneous endoscopic gastrostomy. West China Medical Journal, 2025, 40(1): 17-22. doi: 10.7507/1002-0179.202410312 Copy

1.	中华医学会神经病学分会肌萎缩侧索硬化协作组. 肌萎缩侧索硬化诊断和治疗中国专家共识 2022. 中华神经科杂志, 2022, 55(6): 581-588.
2.	Katzberg HD, Benatar M. Enteral tube feeding for amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database Syst Rev, 2011, 101(1): CD004030.
3.	Yang R, Huang R, Chen D, et al. Causes and places of death of patients with amyotrophic lateral sclerosis in south-west China. Amyotroph Lateral Scler, 2011, 12(3): 206-209.
4.	Miller RG, Rosenberg JA, Gelinas DF, et al. Practice parameter: the care of the patient with amyotrophic lateral sclerosis (an evidence-based review). Muscle Nerve, 1999, 22(8): 1104-1118.
5.	Stambler N, Charatan M, Cedarbaum JM. Prognostic indicators of survival in ALS. ALS CNTF Treatment Study Group. Neurology 1998, 50(1): 66-72.
6.	Burgos R, Bretón I, Cereda E, et al. ESPEN guideline clinical nutrition in neurology. Clin Nutr, 2018, 37(1): 354-396.
7.	Shimizu T, Nakayama Y, Matsuda C, et al. Prognostic significance of body weight variation after diagnosis in ALS: a single-centre prospective cohort study. J Neurol, 2019, 266(6): 1412-1420.
8.	中华医学会神经病学分会肌电图与临床神经电生理学组. 中国肌萎缩侧索硬化诊断和治疗指南. 中华神经科杂志, 2012, 45(7): 531-533.
9.	Printza A, Boziki M, Triaridis S, et al. Tongue strength, dysphagia questionnaire, pharyngeal secretions and FEES findings in dysphagia management in amyotrophic lateral sclerosis. Auris Nasus Larynx, 2021, 48(4): 672-682.
10.	Wei Q, Chen X, Zheng Z, et al. Clinical features of amyotrophic lateral sclerosis in south-west China. Amyotroph Lateral Scler Frontotemporal Degener, 2015, 16(7/8): 512-519.
11.	张新宇, 王丽平, 张俊, 等. 肌萎缩侧索硬化患者使用内镜经皮胃造瘘的影响因素. 世界华人消化杂志, 2011(7): 749-753.
12.	Liu MS, Cui LY, Fan DS, et al. Age at onset of amyotrophic lateral sclerosis in China. Acta Neurol Scand, 2014, 129(3): 163-167.
13.	廉羚, 林伟源, 向贤宏, 等. CT 引导下和内镜下经皮胃造瘘术对肌萎缩侧索硬化患者的疗效观察. 天津医药, 2023, 51(7): 687-690.
14.	Mehta P, Raymond J, Punjani R, et al. Prevalence of amyotrophic lateral sclerosis in the United States using established and novel methodologies, 2017. Amyotroph Lateral Scler Frontotemporal Degener, 2023, 24(1/2): 108-116.
15.	Chiò A, Logroscino G, Traynor BJ, et al. Global epidemiology of amyotrophic lateral sclerosis: a systematic review of the published literature. Neuroepidemiology, 2013, 41(2): 118-130.
16.	Miller RG, Jackson CE, Kasarskis EJ, et al. Practice parameter update: the care of the patient with amyotrophic lateralsclerosis: drug, nutritional, and respiratory therapies (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 2009, 73(15): 1218-1226.
17.	王丽平, 张新宇, 樊东升, 等. 中国肌萎缩侧索硬化患者睡眠相关情况调查. 中国全科医学, 2014, 17(5): 539-541,545.
18.	Wei Q, Chen X, Zheng Z, et al. Frontal lobe function and behavioral changes in amyotrophic lateral sclerosis: a study from Southwest China. J Neurol, 2014, 261(12): 2393-2400.
19.	姜跃龙, Xinsheng Liu, Daniel KY Chan. 内镜下经皮胃造瘘术的并发症及防治进展. 临床消化病杂志, 2013, 25(1): 58-61.
20.	Roveron G, Antonini M, Barbierato M, et al. Clinical practice guidelines for the nursing management of percutaneous endoscopic gastrostomy and jejunostomy (PEG/PEJ) in adult patients: an executive summary. J Wound Ostomy Continence Nurs, 2018, 45(4): 326-334.
21.	Horiuchi A, Nakayama Y, Kajiyama M, et al. Nasopharyngeal decolonization of methicillin-resistant staphylococcus aureus can reduce PEG peristomal wound infection. Am J Gastroenterol, 2006, 101(2): 274-277.
22.	Thomas S, Cantrill S, Waghorn DJ, et al. The role of screening and antibiotic prophylaxis in the prevention of percutaneous gastrostomy site infection caused by methicillin-resistant Staphylococcus aureus. Aliment Pharmacol Ther, 2007, 25(5): 593-597.
23.	Radhakrishnan NV, Shenoy AH, Cartmill I, et al. Addition of local antiseptic spray to parenteral antibiotic regimen reduces the incidence of stomal infection following percutaneous endoscopic gastrostomy: a randomized controlled trial. Eur J Gastroenterol Hepatol, 2006, 18(12): 1279-1284.
24.	梁燕, 李银萍, 陈德智. 肌萎缩侧索硬化患者行经皮内镜下胃造瘘术术后并发症的观察及护理. 华西医学, 2015, 30(9): 1736-1738.
25.	杨玉玲, 孙梦姣, 余红梅, 等. 山西省某医院冠心病病人住院费用分析. 护理研究, 2024, 38(4): 694-697.
26.	唐涛, 王赛, 张雨篷, 等. 湖南省脑出血患者住院费用分析. 中国卫生统计, 2023, 40(1): 99-102.

1. 中华医学会神经病学分会肌萎缩侧索硬化协作组. 肌萎缩侧索硬化诊断和治疗中国专家共识 2022. 中华神经科杂志, 2022, 55(6): 581-588.
2. Katzberg HD, Benatar M. Enteral tube feeding for amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database Syst Rev, 2011, 101(1): CD004030.
3. Yang R, Huang R, Chen D, et al. Causes and places of death of patients with amyotrophic lateral sclerosis in south-west China. Amyotroph Lateral Scler, 2011, 12(3): 206-209.
4. Miller RG, Rosenberg JA, Gelinas DF, et al. Practice parameter: the care of the patient with amyotrophic lateral sclerosis (an evidence-based review). Muscle Nerve, 1999, 22(8): 1104-1118.
5. Stambler N, Charatan M, Cedarbaum JM. Prognostic indicators of survival in ALS. ALS CNTF Treatment Study Group. Neurology 1998, 50(1): 66-72.
6. Burgos R, Bretón I, Cereda E, et al. ESPEN guideline clinical nutrition in neurology. Clin Nutr, 2018, 37(1): 354-396.
7. Shimizu T, Nakayama Y, Matsuda C, et al. Prognostic significance of body weight variation after diagnosis in ALS: a single-centre prospective cohort study. J Neurol, 2019, 266(6): 1412-1420.
8. 中华医学会神经病学分会肌电图与临床神经电生理学组. 中国肌萎缩侧索硬化诊断和治疗指南. 中华神经科杂志, 2012, 45(7): 531-533.
9. Printza A, Boziki M, Triaridis S, et al. Tongue strength, dysphagia questionnaire, pharyngeal secretions and FEES findings in dysphagia management in amyotrophic lateral sclerosis. Auris Nasus Larynx, 2021, 48(4): 672-682.
10. Wei Q, Chen X, Zheng Z, et al. Clinical features of amyotrophic lateral sclerosis in south-west China. Amyotroph Lateral Scler Frontotemporal Degener, 2015, 16(7/8): 512-519.
11. 张新宇, 王丽平, 张俊, 等. 肌萎缩侧索硬化患者使用内镜经皮胃造瘘的影响因素. 世界华人消化杂志, 2011(7): 749-753.
12. Liu MS, Cui LY, Fan DS, et al. Age at onset of amyotrophic lateral sclerosis in China. Acta Neurol Scand, 2014, 129(3): 163-167.
13. 廉羚, 林伟源, 向贤宏, 等. CT 引导下和内镜下经皮胃造瘘术对肌萎缩侧索硬化患者的疗效观察. 天津医药, 2023, 51(7): 687-690.
14. Mehta P, Raymond J, Punjani R, et al. Prevalence of amyotrophic lateral sclerosis in the United States using established and novel methodologies, 2017. Amyotroph Lateral Scler Frontotemporal Degener, 2023, 24(1/2): 108-116.
15. Chiò A, Logroscino G, Traynor BJ, et al. Global epidemiology of amyotrophic lateral sclerosis: a systematic review of the published literature. Neuroepidemiology, 2013, 41(2): 118-130.
16. Miller RG, Jackson CE, Kasarskis EJ, et al. Practice parameter update: the care of the patient with amyotrophic lateralsclerosis: drug, nutritional, and respiratory therapies (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 2009, 73(15): 1218-1226.
17. 王丽平, 张新宇, 樊东升, 等. 中国肌萎缩侧索硬化患者睡眠相关情况调查. 中国全科医学, 2014, 17(5): 539-541,545.
18. Wei Q, Chen X, Zheng Z, et al. Frontal lobe function and behavioral changes in amyotrophic lateral sclerosis: a study from Southwest China. J Neurol, 2014, 261(12): 2393-2400.
19. 姜跃龙, Xinsheng Liu, Daniel KY Chan. 内镜下经皮胃造瘘术的并发症及防治进展. 临床消化病杂志, 2013, 25(1): 58-61.
20. Roveron G, Antonini M, Barbierato M, et al. Clinical practice guidelines for the nursing management of percutaneous endoscopic gastrostomy and jejunostomy (PEG/PEJ) in adult patients: an executive summary. J Wound Ostomy Continence Nurs, 2018, 45(4): 326-334.
21. Horiuchi A, Nakayama Y, Kajiyama M, et al. Nasopharyngeal decolonization of methicillin-resistant staphylococcus aureus can reduce PEG peristomal wound infection. Am J Gastroenterol, 2006, 101(2): 274-277.
22. Thomas S, Cantrill S, Waghorn DJ, et al. The role of screening and antibiotic prophylaxis in the prevention of percutaneous gastrostomy site infection caused by methicillin-resistant Staphylococcus aureus. Aliment Pharmacol Ther, 2007, 25(5): 593-597.
23. Radhakrishnan NV, Shenoy AH, Cartmill I, et al. Addition of local antiseptic spray to parenteral antibiotic regimen reduces the incidence of stomal infection following percutaneous endoscopic gastrostomy: a randomized controlled trial. Eur J Gastroenterol Hepatol, 2006, 18(12): 1279-1284.
24. 梁燕, 李银萍, 陈德智. 肌萎缩侧索硬化患者行经皮内镜下胃造瘘术术后并发症的观察及护理. 华西医学, 2015, 30(9): 1736-1738.
25. 杨玉玲, 孙梦姣, 余红梅, 等. 山西省某医院冠心病病人住院费用分析. 护理研究, 2024, 38(4): 694-697.
26. 唐涛, 王赛, 张雨篷, 等. 湖南省脑出血患者住院费用分析. 中国卫生统计, 2023, 40(1): 99-102.

Previous Article
宏基因组下一代测序技术诊断呼吸道耳念珠菌感染三例
Next Article
Analysis and reflection on the current status of clinical research on rare diseases in China

West China Medical Journal

Research on direct economic burden and its impact factors in hospitalized patients with amyotrophic lateral sclerosis underwent percutaneous endoscopic gastrostomy

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content